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Medications that inhibit CYP2D6 action, for instance paroxetine and quinidine, may perhaps result in lowered clearance of oxycodone which could lead on to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Patients need to be titrated to